• Mohit Goyal Division of Rheumatology and Clinical Immunology, CARE Pain & Arthritis Centre, Goyal Hospital, Udaipur, India
  • Neha Goyal Division of Interventional Pain Management, CARE Pain & Arthritis Centre, Goyal Hospital, Udaipur, India
Keywords: Coronavirus disease 2019, Severe acute respiratory syndrome coronavirus 2, Pandemic, Cholecalciferol, Calcitriol, Clinical trial, Vitamin D, Hypothesis


The coronavirus disease 2019 (COVID-19) pandemic has disrupted the normal activities of various settings, including clinics, laboratories, and libraries. As the world deals with the fast-mutating causative virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), apart from the search for the best vaccine candidate, efforts towards repurposing existing molecules to save lives must continue. Considerable interest has centered around the implications of vitamin D deficiency and its supplementation on the outcomes in patients with COVID-19. We hypothesize that vitamin D supplementation has the potential to confer protection against SARS-CoV-2 infection and a severe COVID-19 course. Various animal, human observational as well as interventional studies have shown a protective role of vitamin D in COVID-19. More robustly designed studies where vitamin D is supplemented prophylactically and administered to those already infected are needed to determine the precise contribution of this supplementation in preventing SARS-CoV-2 infection and modifying the course of COVID-19.


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