GENERATING WORKING HYPOTHESES FOR ORIGINAL RESEARCH STUDIES
Abstract
A hypothesis is a statement of the expected outcome of a research study, generally based on analysis of prior published knowledge, or with reference to the previous work of the investigators. The hypothesis forms the foundation of a research proposal. A study based, and planned, on a sound hypothesis may have a greater likelihood of meaningfully contributing to science. After the generation of a hypothesis, it is equally important to appropriately design and adequately power a study (by ensuring a sufficient sample size) in order to test the hypothesis. Adhering to principles discussed forthwith shall help young researchers to generate and test their own hypotheses, and these are best learnt with experience.
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Maqbool F, Bahadar H, Abdollahi M. Science for the benefits of all: The way from idea to product. J Med Hypotheses Ideas 2014;8(2):74–77.
Thiese MS. Observational and interventional study design types; an overview. Biochem Med 2014;24(2):199–210.
Tully MP. Research: articulating questions, generating hypotheses, and choosing study designs. Can J Hosp Pharm 2014;67(1):31–34.
Leon-Mimila P, Wang J, Huertas-Vazquez A. Relevance of Multi-Omics Studies in Cardiovascular Diseases. Front Cardiovasc Med 2019;6:91.
Rajkomar A, Dean J, Kohane I. Machine Learning in Medicine. N Engl J Med 2019;380(14):1347–1358.
Leppink J, O'Sullivan P, Winston K. Evidence against vs. in favour of a null hypothesis. Perspect Med Educ 2017;6(2):115–118.
Gasparyan AY, Ayvazyan L, Blackmore H, Kitas GD. Writing a narrative biomedical review: Considerations for authors, peer reviewers, and editors. Rheumatol Int 2011;31(11):1409–1417.
Gasparyan AY, Yessirkepov M, Voronov AA, et al. Specialist bibliographic databases. J Korean Med Sci 2016;31(5):660–673.
Shenoy PD, Kumar S, Jha LK, et al. Efficacy of tadalafil in secondary Raynaud's phenomenon resistant to vasodilator therapy: a double-blind randomized cross-over trial. Rheumatology (Oxford) 2010;49(12):2420–2428.
Ahmed S, Rai MK, Misra DP, Agarwal V. Tadalafil reduces skin fibrosis and profibrotic genes expression in patients with systemic sclerosis (abstract). Arthritis Rheumatol 2017;69 (suppl 10).
Agarwal V, Rai MK, Agarwal V, Singh H, Chaturvedi S. Phosphodiesterase-5 Inhibitors Attenuate Fibrotic Phenotype and Restore Anti-Fibrotic Resopnses of Cutaneous Fibroblasts in Patients with Scleroderma [abstract]. Arthritis Rheumatol 2016;68 (suppl 10).
Jolly M, Fletcher AC, Bourne PE. Ten Simple Rules to Protect Your Intellectual Property. PLOS Comput Biol 2012;8(11):e1002766.
ICMJE recommendations. Available from: http://www.icmje.org/icmje-recommendations.pdf [Accessed Aug 11, 2019].
Marín-Franch I. Publication bias and the chase for statistical significance. J Optom 2018;11(2):67–68.
Banerjee A, Chaudhury S. Statistics without tears: Populations and samples. Ind Psychiatry J 2010;19(1):60–65.
Akobeng AK. Understanding type I and type II errors, statistical power and sample size. Acta Paediatr 2016;105(6):605–609.
Whitley E, Ball J. Statistics review 4: sample size calculations. Crit Care 2002;6(4):335–341.
Kanji S. Turning Your Research Idea into a Proposal Worth Funding. Can J Hosp Pharm 2015;68(6):458–464.
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